Lipid Profile, Nutritional Status and Severity Biomarkers in Adults With Sickle Cell Anemia

BACKGROUND Lipid alterations have been described in sickle cell anemia (SCA), but their association with the disease severity is not fully understood and correlation nutritional status of this population has widely studied. OBJECTIVES This study aimed to assess lipid profile its relation status, including anthropometric characteristics daily macronutrient intake, biomarkers adults SCA a steady state. DESIGN Cross-sectional METHODS was an analytical cross-sectional 55 60 members control group. Sociodemographic, anthropometric, nutritional, laboratory data were collected between March 2019 June 2020. Mann–Whitney test used compare groups Spearman's coefficient variables. RESULTS The group presented higher calorie, protein, carbohydrate lower levels high-density lipoprotein-cholesterol (HDL-c), triglyceride (TG)/HDL-c ratio than control. HDL-c showed positive hemoglobin hematocrit (HcT) negative indirect bilirubin lactate dehydrogenase (LDH). TG/HDL-c positively linked reticulocyte count, LDH, leukocyte count negatively Hb. CONCLUSIONS findings hypocholesterolemia independent intake. links hemolysis indices indicate that they are easily accessible, low-cost markers capable predicting severity.